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2019 Sweet 16 Betting Odds and Matchups

Virginia Tech Hokies vs. Duke Blue Devils

Despite being the top seed overall in the tournament, the Duke Blue Devils were one roll away from watching the rest of the tournament from their homes after the Knights of Central Florida pushed them to the brink in the second round. With that being said, the Blue Devils are still the heavy favorites to win the title, thanks to the strong play of the freshmen trio of Zion Williamson, RJ Barrett, and Cam Reddish, all of who are expected to go in the first round of this year’s NBA Draft, with Williamson and Barrett expected to go in the first three picks.

The Virginia Tech Hokies aren’t going to roll over though. The last time the two teams met in the regular season, the Hokies sent the Blue Devils back home with a loss in a 77-72 upset in Blacksburg. While Zion Williamson didn’t play in that game, the Hokies were also without senior guard Justin Robinson, who is expected to play in this upcoming matchup. Virginia Tech hasn’t been in the Sweet Sixteen since 1962 and they’ll be doing everything they can to make sure their ride doesn’t end here, despite their tough test on Friday.

Gonzaga and Duke have been dominant, can they make it to the Championship game? Find the best Sweet 16 betting odds and March Madness futures and prop bets right here at, register now to receive the biggest college basketball betting bonuses and promotions.

Oregon Ducks vs. Virginia Cavaliers

The second favorite to cut down the nets is the Virginia Cavaliers, who avoided the first-half scare against Gardner-Webb that brought back flashbacks of last year’s historic upset to UMBC before dispatching Oklahoma in the second round. The Cavaliers are led by junior guards Kyle Guy and Ty Jerome and sophomore guard De’Andre Hunter, who are hungry to prove themselves after last year’s tournament failures. The Cavaliers will stick to their game plan of a slow-tempo, defensive game that stifles opponents.

The Oregon Ducks may be the lowest-seeded team in the Sweet Sixteen, but as they’ve proved already in the tournament, you can’t count them out. Counting their two tournament victories over Wisconsin and UC-Irvine, the Ducks have won their last 10 games. The Ducks won their tournament games by an average of 18.5 points, but they’ll face a much stiffer task against the Virginia defense.

Florida State Seminoles vs. Gonzaga Bulldogs

Two years removed from falling short of the title, the Gonzaga Bulldogs are hoping to reach the mountaintop this season, and there’s reason for optimism for the Zags, led by potential lottery pick Rui Hachimura and likely first-rounder Brandon Clarke. In their path are the Florida State Seminoles, who may be without senior forward Phil Cofer, who learned of the death of his father after the Noles’ first-round win over Vermont.

Purdue Boilermakers vs. Tennessee Volunteers

The Purdue Boilermakers meet the Tennessee Volunteers in Louisville for their Sweet Sixteen matchup and will feature two of the most exciting guards in college basketball going head to head in Purdue’s Carsen Edwards and Tennessee’s Admiral Schofield.

Texas Tech Red Raiders vs. Michigan Wolverines

The Texas Tech Red Raiders, with potential lottery pick Jarrett Culver, may be one of the more underrated teams, as much as a three-seed can be underrated, and they’ll be able to prove it with a win over the Michigan Wolverines. But the Wolverines boast an experienced team that made it to last year’s championship game led by senior Charles Matthews and sophomore Jordan Poole along with freshman Ignas Brazdeikis.

LSU Tigers vs. Michigan State Spartans

After squeaking by the Maryland Terrapins in the second round, the LSU Tigers will face a tougher test in the Michigan State Spartans, who are back for their 14th Sweet Sixteen under coach Tom Izzo. The Tigers, which are under an investigation and without head coach Will Wade, would love to prove the doubters wrong once more but will need to find a way to contain Spartan point guard Cassius Winston.

Auburn Tigers vs. North Carolina Tar Heels

After surprising many people by winning the SEC Tournament title, Bruce Pearl’s Auburn Tigers are continuing to win behind Bryce Brown, easily dispatching the Kansas Jayhawks in the second round. The North Carolina Tar Heels, picked by many to win it all for the second time in three years, are led by a balanced attack by Cam Johnson, Coby White, and Luke Maye.

Houston Cougars vs. Kentucky Wildcats

Back in the Sweet Sixteen for the first time since the years of Hakeem Olajuwon and Phi Slama Jama, the Houston Cougars are crashing the boards through the tournament, dominating the rebounding stat box against their first two opponents. The Kentucky Wildcats are hoping to have star sophomore forward PJ Washington, who missed the first two games with a foot injury, back to help them with rebounding and scoring, but they’ve shown they have players that are more than capable of stepping up in big situations.

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