1-888-759-2665Backup: 1-888-740-1958 

NFL Week 16: 49ers vs. Rams Betting Odds, Betting Matchups

A big NFC West clash is awaiting at NFL’s Week 16! The Seahawks and 49ers already got their tickets for the postseason, and even though there are still slight chances for the Rams to make it to the playoffs, a loss to San Francisco will end up with their hopes for good.

The Rams are coming from a 44-21 loss to the Cowboys at Dallas as 1-point road favorites. And, after that defeat, the team’s figures for this season dropped to 9-5 ATS and 8-6 SU.

The 49ers allowed the Falcons their fifth win of the current season, in what ended up being a close 29-22 defeat that is leaving their record at 11-3. This actually meant the second straight up loss for San Fran in the past 3 weeks. The team is now 8-5-1 ATS and 11-3 SU this present season.

The 49ers are opening as 6.5 favorites, and a big reason for this –besides playing at home – is the fact that San Francisco took the first game between these two this season 20-7.

Current 49ers vs. Rams odds are:

  • Los Angeles Rams +6½-110, O45-110, +235
  • San Francisco 49ers -6½-110, U45-110, -275

Register now to bet on the 49ers vs. Rams game on Week 16. Enjoy the best NFL live betting experience at Skybook and biggest selection of football prop bets and futures.

LA performed quite poorly versus San Fran in October, averaging only 3.1 yards per play, and they were also 0-9 on third downs versus the 49ers.

This is going to be the very first time that LA is playing as road underdogs of 6.5 points or more since the 2016 season. The Rams are 3-7 ATS and SU in their last ten in that particular situation. The 49ers have played as 6.5-point or more favorites a total of 3 times this year, and they were 0-2-1 ATS and 1-2 SU, with the total going OVER for those 3 matches.

San Francisco 49ers Betting Odds

The injury report for this team is pretty bad. First, we have Richard Sherman, who’s expected to play, but remains questionable as he’s currently suffering a hamstring injury.

Other players with the question mark above their heads are Jullian Taylor (elbow), Jaquiski Tartt (ribs), Dee Ford (hamstring), and Kwaun Williams (concussion). And one player that will definitely not make it to this game is DJ Jones, who was added to the injured reserve list last week as he suffered an ankle injury.

With a lot of defensive lineup injuries, it’s quite possible that the defense for the 49ers will look pretty different than that one which held LA to a low seven points. Their offensive is also a bit worrisome, as they scored 48 versus the Saints, but then were held to just 22 points versus Atlanta, a team with a below-average defense.

Get ready for the best 49ers betting lines when you bet at Skybook Sportsbook Online. Register now to enjoy the best NFL betting action.

During the victory over NOLA, Jimmy Garoppolo finished with 4 touchdowns passes and 349 yards, while his team averaged a total of 6.8 yards per carry as a franchise. The 49ers were six-for-twelve on third downs and four-for-six in the red zone.

Versus Atlanta, the starting quarterback for San Francisco posted only two hundred passing yards, and the team was able to convert 4 of twelve on third down. The big factor for all the 49ers victories this season is the trust Garoppolo has deposited on George Kittle.

Los Angeles Rams Betting Odds

Before their loss to Dallas, LA was rolling on a 3-game streak. And Tom Gurley was phenomenal during those 3, producing the following stats:

  • 23 carries for 79 yards and a TD
  • 19 carries for 95 yards and a TD
  • 25 carries for 97 yards and a TD

Gurley’s figures went down versus the Cowboys, finishing with just 11 carries for twenty yards versus a franchise with a rush defense that had allowed more than one hundred yards per game before this meeting. Things are promising once again, as LA’s starting quarterback will be facing the 49ers, a team that has allowed 128 rush yards or more per game over their last 3 games. Gurley can be the surprise factor, as he missed the first game versus San Fran due to a bruised thigh.

During their past two victories, the Rams were able to convert 15 of 28 third downs, which equals 53.5%, but versus Dallas, the team was able to convert only 33%.

Get ready for the best Rams betting lines when you bet at Skybook. Register now to enjoy the best NFL betting action.

While the third-down defense for San Francisco has gone backward a little bit for the past three weeks they are still ranking second in the NFL, with the offensive lineups of their rivals converting just 30.9% of third downs versus the 49ers this year.

When it comes to injuries, tackle Rob Havenstein and TE Gerald Everett are questionable to play at Week 16. And CB Troy Hill is set to undergo thumb surgery, but he may be able to get the green light to play the Niners.

Rams at 49ers Betting Trends

  • The Rams are 7-2 ATS in their last 9 road games.
  • The 49ers are 2-7-1 ATS in their last 10 NFC West games.
  • The Rams are 6-0 ATS in their last 6 games after an ATS loss.

Will the 49ers get this win at home or will the Rams claim their ninth victory of the season allowing them to keep the postseason flame alive?

Register now and bet on your favorite Week 16 games!

NFL Live Lines

Live Lines Menu
No Live Lines available to print in this moment.